I think it would be in Pakistan's interest to split from CIA.
Global politics has changed a lot since past 10 years. China is an emerging superpower and a close ally of Pakistan and Pakistan needs China for development and because both China and Pakistan share a mutual enemy --- India.
With China becoming an emerging superpower, U.S. sees China as a big threat and therefore U.S. is getting cozy with China's enemies especially India.
Basically U.S. and India today share the same strategic interests in Asia. Pakistan and China share the same strategic interests in Asia. U.S. has no problem with Indian presence in Afghanistan while Pakistan sees India's presence in neighboring Afghanistan as a huge threat ( the reason why we helped defeat the Soviets was because we didnt want to be surround by the enemy on both sides).
When U.S. leaves Afghanistan, it plans to install permanent American and Indian "chowkidars" to cause problems for Pakistan and China, thats why ISI should not work for CIA/America's interests and should only worry about Pakistan's interests in Afghanistan and in the entire Asian continent.