Undiscovered form of resistance to HIV?

[VCheng]

If this is true and confirmed, it could be important:

Woman 'fights off HIV without drugs' may have resistance to the virus  | Daily Mail Online

Woman, 18, 'fights off HIV without drugs': Doctors say patient who stopped treatment 12 years ago may have undiscovered form of resistance to the virus

• Unexplained resistance has left scientists baffled by her remission
• Teenager may have some form of natural resistance to HIV
• It is not the first case: a Mississippi girl survived HIV without treatment for around 27 months

An 18-year-old French girl born with the AiIDS virus has had her infection under control and nearly undetectable despite stopping treatment 12 years ago — an unprecedented remission, doctors are reporting.

The teenager might have some form of natural resistance to HIV that hasn’t yet been discovered. But her case revives hope that early, aggressive treatment can limit how strongly the virus takes hold, and perhaps in rare cases, let people control it without lifelong drugs.

A few years ago, doctors reported a similar case: a Mississippi girl who kept HIV in check for 27 months without treatment. But then her virus rebounded, dashing hopes that early treatment might have cured her.

 

[Nefarious]

Probably smokes marijuana.

 

[knight11]

Most of the funds in the research is on the treatment of the HIV virus and very less in the research in vaccination. HIV resistance animal antigen could be the answer for this. Mutation and multiple mutation in HIV virus confer the high level resistance to ATZ.

 

[he-man]

Maybe she has mutation in ccr5 and cxcr4 receptors but such people never even develop the symptoms in the first place as virus cannot invade the macrophages.

 

[knight11]

Maybe she has mutation in ccr5 and cxcr4 receptors but such people never even develop the symptoms in the first place as virus cannot invade the macrophages.

Or the DNA structure prevents transcription of the viral DNA into mRNA. But the patients eventually is infected with HIV but showing great resistance that means presence of some protien or enzyme which is creating problems for the virion buds to propagate easily.

 

[fenku]

It is true some ppl have capability of HIV resistance...

 

[maxpayne]

Ur POV please @syedali73

 

[yuba]

I remember a show on a man whose partner died of aids.He got tested and was negative they found out he was missing a receptor or something like that and basically was immune to hiv.

Maybe she has mutation in ccr5 and cxcr4 receptors but such people never even develop the symptoms in the first place as virus cannot invade the macrophages.

Sorry mate did not read your post before writing mine.

 

[he-man]

It is true some ppl have capability of HIV resistance...

Yup as i already told,,receptor mutations.

 

[knight11]

It is true some ppl have capability of HIV resistance...

Some people have high resistance for HIV to be developed in AIDS. Many rumours but it is the nature and diversity which makes it possible but if a person is completely resistance to HIV infection how would some one discover. If found could lead us to the antigen which will make the true HIV vaccination and medicine thats how man have discovered other antigens. Problem is that infected cell whose DNA is overwritten with the HIV RNA has many forms or it in other word it can also mutate.

 

[indianBong]

Maybe she has mutation in ccr5 and cxcr4 receptors but such people never even develop the symptoms in the first place as virus cannot invade the macrophages.

On topic....Correct.....
(Off topic: welcome back bro...)

 

[syedali73]

Ur POV please @syedali73

She appears to belong to a group we call 'elite responder'; some 1% HIV positive patients fall in the category of 'elite responder', for immune system of such patients is capable of keeping the HIV population at low level without or with little therapeutic intervention. I was trying to find any research paper published on this case for only after going through the details would I be able to comment with certainty. Dr Saez-Cirion of Institut Pasteur in Paris has presented this case at the recently held International Aids Society's conference and I guess a case report/research paper will soon appear detailing the findings.

Thanks for tagging me.

 

[maxpayne]

She appears to belong to a group we call 'elite responder'; some 1% HIV positive patients fall in the category of 'elite responder', for immune system of such patients is capable of keeping the HIV population at low level without or with little therapeutic intervention. I was trying to find any research paper published on this case for only after going through the details would I be able to comment with certainty. Dr Saez-Cirion of Institut Pasteur in Paris has presented this case at the recently held International Aids Society's conference and I guess a case report/research paper will soon appear detailing the findings.

Thanks for tagging me.

Thank you for details. Please share & tag research paper if u find it.