More than four cups of coffee a day puts you at risk of early death: experts
ISLAMABAD: US researchers found more than 28 cups of coffee in a week increases by half the chances of premature death in younger people If youre already holding your first coffee of the morning, you might want to put it down.
Because of drinking coffee four cups a day could raise your risk of dying young, researchers warn but only if youre under 55, Health News reported.
They found that consuming 28 cups of coffee a week increases the chances of premature death in younger people by half.
The findings come from a large- scale American lifestyle study of 43,727 individuals aged 20 to 87.
The US researchers suspect excessive coffee consumption may adversely affect the bodys metabolism, outweighing some of the known health benefits.
Individuals with a `genetic coffee addiction may be prone to these harmful effects, they suggest.
But the latest study conflicts with a number of others, which have linked moderate coffee consumption with longevity.
Around 2,500 deaths were recorded over the course of the 16-year study.
Just under a third of these were because of heart and artery disease.
Participants who drank more coffee were also more likely to smoke, and had less healthy hearts and lungs.
The risk of death from all causes rose by 56 per cent for men and women younger than 55 who drank more than 28 cups of coffee a week, said a report in the journal Mayo Clinic Proceedings.
Scientists suspect excessive coffee consumption may adversely affect the bodys metabolism, outweighing some of the known health benefits
Researcher Steven Blair, of the University of South Carolina, said: Significantly the results did not demonstrate any association between coffee consumption and all-cause mortality in older men and women.
But the researchers did not explain why coffee did not affect older people in the same way. Coffee contains thousands of different chemicals, which can have both good and bad effects on health.
Mouth bacteria may trigger bowel cancer: US researchers said they have discovered that a common oral bacterium can trigger a cascade of changes leading to colorectal cancer. The microorganism called fusobacteria, which are found in the mouth, may stimulate bad immune responses and turn on cancer growth genes to generate colorectal tumors, two studies published in the journal Cell Host and Microbe revealed.
Colorectal cancer is the second leading cause of cancer- related death in the United States. Recent studies have shown that fusobacteria from the mouth are also abundant in tissues from colorectal cancer patients but it was not known whether they directly contribute to the formation of tumors, BBC reported
In one of the new studies, Professor Yiping Han from the Case Western Reserve University School of Dental Medicine and her collaborators discovered that fusobacteria rely on a molecule called FadA, which is found on the surface of these bacterial cells, to attach to and invade human colorectal cancer cells.
FadA then turns on cancer growth genes and stimulates inflammatory responses in these cells and promotes tumor formation, Han said.
Hans team also found that the FadA gene levels are 10 to 100 times higher than normal in precancerous and malignant colon polyps.
Moreover, they identified a compound known as peptide that can prevent FadAs effects on cancer cells. We showed that FadA is a marker that can be used for the early diagnosis of colorectal cancer and identified potential therapeutic targets to treat or prevent this common and debilitating disease, Han said.
In the second study, researchers from the Harvard School of Public Health and the Dana-Farber Cancer Institute found that fusobacteria are prevalent in human adenomas, or benign tumors that can become malignant over time, suggesting that these microbes contribute to early stages of tumor formation.
In a mouse model of colorectal cancer, these bacteria accelerated the formation of tumors by attracting immune cells called myeloid cells, which invade tumors and stimulate inflammatory responses that can cause cancer, they said.
The findings will not only lead to more effective strategies for the early diagnosis, prevention, and treatment of colorectal cancer, but also show the importance of good oral health, Han added. agencies.
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