First of all, stories like these are extremely common in India as well. There is a sustained belief among many concerning dayans, churails, pret-aatmas, nishachars (flesh-eating demons), and a million other things. In Islamic belief system, all these entities are probably given a catch-all phrase: jinns. In Europe and America, of course, there is sustained belief in vampires, witchcraft, and other dark forces of nature.
The Qu'ran has some good lines to stave off these darker forces of nature: the Surah Al' Falak which means you implore Allah to give you refuge from such forces. The Bible has Psalm 23 "The LORD is my shepherd; I shall not want....Valley of Shadow of Death". The Hindus have Hanuman Chalisa to ward off evil forces. Most will claim that it does work, so you might wanna try that one.
Religion aside, what is a rational mind supposed to do? Most of these thoughts you're having now are nothing but mind tricks. The eggs in your door step, the crazy aunts (trust me, we all have them even in India. Probably crazier.) are nothing but a figment of imagination. Just because you think your phupi wishes you harm does not mean that her wish will come true.
Your own mental defences are weak, and if you should be angry at someone, make sure you blame yourself first. You have allowed your mind to be controlled by forces beyond your control. So, if the Jinns or churails/bhoot prets are winning, you have nothing but yourself to blame.
But really it sounds like you dislike being in the company of those people. You don't have to put up with them, just move out elsewhere. A US visa rejection is not the end of one's life. If you don't have more important things in your life than a US visa, that's also when you should blame yourself. Assuming you don't want to live in Pakistan, move to another country with easier visa systems. Ask your wife and kids to move to that country of your choice, if they want to live with you (maybe they don't want to live in Pakistan). I am sure you know how to convince them.
I wouldn't worry too much about your deluded
phupis. They can babble all kinds of nonsense. It will have no bearing in your life unless you really want them to.
And if you do end up confronting evil Satan himself, say hello to him on my behalf. I think Satan has more important things to do than bother with ordinary humans.
My conclusion is you have a weak mind. Honestly
if I were you, I'd be ashamed of myself before blaming any random phupis. You need a higher purpose in life which should be more important than a US visa. I understand America is a magical country and you hate not living there. I was there too, however not living in America is not the end of one's life.
These stupid totkas have only as much power as you want them to have. I am capable enough to confront Uncle Satan himself, you only need confidence in your own abilities.
But really for you, it seems it's all about the US visa. You're pretty peeved about it. In the worst case, accept it as your destiny in life. For God's sake, stop blaming others.
Thank you