While every superpower has its own interests to look after, there are certain relationships that are considered beyond comprehension.
Consider US-Israel relationship. US doesn't give a shit when it comes to Israel's existence. Similarly, I remember once a Chinese official irked a US diplomat by telling him "Pakistan is our Israel, you got a problem with that?".
Pakistan has such relationships with Saudi Arabia and Turkey as well. For Saudi Arabia, it's not because of, as some Indians think, a master slave relationship. It's because two holy mosques are situated there. It's well understood that Pakistan's armed forces, and Pakistani public will do anything to protect the holy places.
For Turkey, it's because of Saltanat e Usmania. Most Indians don't even know what it meant to our forefathers. My maternal great grand father was from Turkey and he married an Indian Muslim lady.
For China, I don't know, we have an unconditional love. It is something that is taught to us from the very beginning. For example, I have been told by my parents and grand parents that one country that we can trust, no matter what happens, is China. This friendship bond started when China was going through the tough times in 60s and 70s and now has become even more stronger.
India doesn't enjoy this kind of relationship with any country. India-US relationship is due to the fact that India is a big market for them now with increased purchasing power of Indians. Which idiot country wants to lose a market with over one billion people, more than half of which have enough purchasing power. They didn't have this love when India was relatively poor. On the other hand, China doesn't care about India and Indian market. Had they only considered business, they would have had preferred India over Pakistan some 15 years back. This shows the difference between real friends and fake time passers.
The summary: India will not be able to isolate Pakistan ever, not even in their dreams, even if the business interests do not match, unless Turkey, China and all OIC countries cease to exist on the planet earth.