China Science & Technology Forum

[BoQ77]

Cpl Anna Cross, the U.K. military worker tested positive for Ebola, was the first person in the world to be treated with the experimental Ebola drug MIL 77 and was released from hospital after making a full recovery. The doctors treating her confirmed it is too soon to speculate if the drug helped in her recovery

They described the drug she was given as a close relative of the medicine ZMapp - which British nurse William Pooley received when he was treated for Ebola.
Experts at the Royal Free said MIL 77 was made in China and that a limited supply was available, should anyone need it.
It is too soon to know what role the drug played in Cpl Cross's recovery, they added.

Back in Britain, the decision to try MIL 77 was not difficult. “I said ‘I have Ebola, so, yes, I’d rather have that than high-dose vitamin C,’” she said.

She thanked her doctor, Mike Jacobs, an infectious disease consultant, and her team of clinicians, adding: “Thanks to them I’m alive”.

Cpl Cross joined the Army reserves in 2013 and now plans to return to “military fitness”. She would have no qualms about going back to treat more Ebola patients, but does not think it is likely since the virus now appears to be under control.

Dr Jacobs said it was too early to draw conclusions about the drug’s effectiveness. He said: “I can’t attribute Anna’s recovery to the medicine. On the other hand, we wouldn’t have used the medicine unless it was hopefully going to be of benefit to her.”

Nina Pham gets a hug from Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, outside of National Institutes of Health in Bethesda, Maryland on Friday. Pham, diagnosed with Ebola Oct. 12 after treating an infected man at a Dallas hospital, is free of the virus. (AP Photo/Pablo Martinez Monsivais)

Amber Joy Vinson was diagnosed with Ebola on Oct. 15. Just one week later, her family released a statement that she no longer had the disease.

 

[Keel]

It is interesting for the British medical team to risk trial of the experimental drug made in China since they have successfully applied Z-Mapp to cure four patients before. May be Z-Mapp is out of stock.
Also it is not told in the news why they were going to give MIL-77 a chance for clinical trial assuming there could be also some other trial drugs available on the shelves already like the following vaccines from Canada (VSV-EBOV) and another medical source from China (JK-05) and also from other big drug/pharma manufacturers like GSK, Merck, Johnson and Johnson

Ebola: The race for drugs and vaccines - BBC News

Cure For Ebola Found: Canada To Ship 800 Vials of Experimental Vaccine, China Claims To Have Found Cure : News : TravelersToday

Long-sleeve dance China

 

[xunzi]

Wonder how the West is going to spin this into another "evil China" story?

If it works, expect them to say we copy their medicine. If it doesn't work, the evil Chinese poor medicine is killing their girl! LOL

 

[Aepsilons]

Excellent news!

 

[Keel]

China's medical team have successful cured ebola patients in Liberia in January 2015

Could this be the missing link to the Briitish medical team's confidence in trying MIL-77 on Cpl Cross
although the article in the OP said Cpl Cross was the "first" patient gotten cured by this new drug.

If the Liberian patients were not cured by MIL-77, then which drug has done the job so well in Liberia?


allAfrica.com: Liberia: China-Team Cures Three Liberian Ebola Patients
14 JANUARY 2015

Beijing — The China-financed Ebola Treatment Unit (ETU) in Liberia discharged three Ebola patients on Monday after they all tested negative for the virus twice, the Chinese Foreign Ministry said Tuesday.

The three patients, two women and a seven-year-old boy, were found to be infected with the virus in December, spokesman Hong Lei said, adding that after 20 days of treatment at the Chinese facility all three were given the all clear.

China is encouraged by these success stories, Hong said, adding that it was willing to work closely with the international community to help those West African countries struggling to contain the outbreak of Ebola, Hong said.


The 163-member Chinese medical team, formed by the Chinese People's Liberation Army (PLA), has treated 67 patients since Dec. 23 last year, including five confirmed and 45 suspected patients.

Liberian Assistant Health and Social Welfare Minister Tolbert Nyenswah said President Ellen Johnson Sirleaf extended thanks to China for its assistance, according to Hong.

Liberia has the highest death toll from Ebola in West Africa, which stood at 3,471 by the end of last December, followed by Sierra Leone and Guinea.



Hereuneder are 2 earlier reports on the other Chinese trial drug "JK-05" posted by @TaiShang and @Nan Yang respectively

China firm eyes quick approval of drug to cure Ebola
China approves its first Ebola drug

"The Teahouse Master"
Clay Figurine Zhang Production, Tianjin

 

[ravi kiran]

thanks to china. they have done excellent work. hope Chinese will provide this drug to poor African nations free of cost.

 

[dlclong]

Thanks to those scientists
Thanks to the contribution they make.

 

[ChineseTiger1986]

China is now viewed with a savior image.

 

[war is peace]

Ffs china keep.this drug to your allies not the enemy. How many times have west gave china medicine.

 

[CN.Black]

MIL77 is the improved version of ZMapp.ZMapp can only be strored at 4 centigrade.But MIL77 can be stored at 25 centigrade.

 

[Aepsilons]

It is TOGETHER that we (humanity) can achieve the impossible. China is an indispensable and totally important member of the global family in helping stabilize war torn regions and also health emergencies.

Congratulations to China!!

 

[Keel]

MIL77 is the improved version of ZMapp.ZMapp can only be strored at 4 centigrade.But MIL77 can be stored at 25 centigrade.

Your information is different from the following report

"军事医学科学院陈薇团队研发的疫苗不仅防控针对性强，而且是全球首创埃博拉疫苗冻干粉剂型，37℃环境下可稳定存储2周以上，具备大规模生产条件，适合疫苗冷链条件难以保障的西非热带地区广泛使用，而国外正在进行临床研究的埃博拉疫苗均为1976基因型液体苗，需在-80℃条件下保存和运输。"

So MIL77 excels over ZMapp in

1. it is developed from as recent genetic strands of ebola as 2014 (1976 strands were used for ZMapp)

2. the drug can be stored and still maintain its potency for longer periods (2 weeks) at higher temperature (37 ℃) while ZMapp has to be stored at minus 80℃

MIL77 is a lot more friendly to the clinical environment especially when the drug has to be transported and used for patients in Africa

3. it is ready for mass production

The story here: 上海市疾病预防控制中心网


Now the important link for the clinical trial on Cpl Cross can be traced to this paper published in Lancet:

http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)60553-0.pdf

Therefore before Lancet an important ground work has been laid by a team of Chinese medical professionals and volunteers who have been willing to take part in the trial tests in Taizhou, China, many days before Cpl Cross' treatment in UK

"A team of Chinese researchers, led by Zhu Fengcai with the disease prevention and control center in Jiangsu Province, tested the vaccine's safety in 120 individuals from the province."

New Ebola trial vaccine by Chinese researchers safe: Lancet - World - Xinhua Africa
中国埃博拉疫苗I期临床试验有效获权威认可-中国法院网

Good luck and thank you all

Chinese Art print Painting

 

[scholseys]

Ffs china keep.this drug to your allies not the enemy. How many times have west gave china medicine.

You sir are a moron!

 

[CN.Black]

Your information is different from the following report

"军事医学科学院陈薇团队研发的疫苗不仅防控针对性强，而且是全球首创埃博拉疫苗冻干粉剂型，37℃环境下可稳定存储2周以上，具备大规模生产条件，适合疫苗冷链条件难以保障的西非热带地区广泛使用，而国外正在进行临床研究的埃博拉疫苗均为1976基因型液体苗，需在-80℃条件下保存和运输。"

So MIL77 excels over ZMapp in

1. it is developed from as recent genetic strands of ebola as 2014 (1976 strands was used for ZMapp)

2. the drug can be stored and still maintain its potency for longer periods (2 weeks) and at higher temperature (37 ℃) vs minus 80℃ for ZMapp

3. it is ready for mass production

The story here: 上海市疾病预防控制中心网

Now the important link for the clinical trial on Cpl Cross can be traced to this paper published in Lancet:

http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)60553-0.pdf

Therefore before Lancet an important ground work has been laid by a team of Chinese medical professionals and volunteers who have been willing to take part in the trial tests in Taizhou, China, many days before Cpl Cross' treatment in UK

"A team of Chinese researchers, led by Zhu Fengcai with the disease prevention and control center in Jiangsu Province, tested the vaccine's safety in 120 individuals from the province."
New Ebola trial vaccine by Chinese researchers safe: Lancet - World - Xinhua Africa
中国埃博拉疫苗I期临床试验有效获权威认可-中国法院网

Good luck and thank you all

Chinese Art print Painting

Thank you for your correction.I got the imformation from Baidu Tieba.It seems it's wrong.

 

[Shotgunner51]

China conducts debut launch of Long March 6 | NASASpaceFlight.com

China conducts debut launch of Long March 6
September 19, 2015 by Rui C. Barbosa

China initiated a new era in its space exploration with the debut of a new family of launch vehicle. The first Long March-6 (Chang Zheng-6) rocket was successfully launched from the Taiyuan Satellite Launch Center, with a multi-payload cargo of 20 small satellites. Launch took place at 2300:00 UTC on Saturday.

Long March 6:

• The CZ-6 Chang Zheng-6 is a liquid-propellant, small-load space launch vehicle developed by Shanghai Academy of Spaceflight Technology (SAST).

• The launch vehicle is based on the 3.35m-diameter boosters, which have been developed as a strap-on booster for the CZ-5 family of SLV.

• The core stage consists of a single 120t-thrust YF-100 engine that burns oxygen and kerosene (LOX/Kerosene) propellant, which causes less pollution compared to the UDMH/N2O4 (nitrogen tetroxide) propellant currently in use.

• The Long March-6 is designed for small-load launch missions, with a sun-synchronous orbit (700km SSO) capability of 1,080 kg.

• In September 2009, the Chang Zheng-6 launch vehicle development program was officially approved by the Chinese Government and the first flight was expected to take place in 2013. SAST was tasked with the development of the new launch vehicle in July 2008.

• Overall length is 29.237 m with a total mass at liftoff of 103,217 kg. Dry mass of the three stages combined is 9,020 kg. Fairing diameter is 2.25 m / 2.6 m, and the vehicle is capable of launching a payload of 1,080 kg to a 700 km SSO orbit (500 kg if only Chinese tracking stations are used).

• The first stage has a 3.35 meter diameter and is equipped with a single YF-100 engine, consuming 76,000 kg of kerosene RP-1/LOX. The YF-100 engine is capable of a ground thrust of 1,177 kN and a ground specific impulse of 2.9 km/s. Burn time is 155 seconds. The first stage uses four 1000 N thrusters for roll control.

• The second stage has 2.25 meter diameter and consumes 15,150 kg of kerosene RP-1/LOX. It is equipped with a YF-115 developing 147.1 kN (sea level) or 176.5 kN (vacuum), with a vacuum specific impulse of 3.35 km/s. The second stage uses four 25 N thrusters for roll control.

• The third stage is equipped with four engines with 4 kN (each), along with eight 100 N thrusters for attitude control. The engines are powered by a mixture of kerosene and hydrogen peroxide.

The Long March-6 first cargo: Twenty small Chinese satellites are the cargo of the Long March-6 first mission.

• The ZDPS-2 Zheda Pixing-2 satellites is a dual satellite platform mission designed by Zhejiang University to provide a technology demonstration of guidance, navigation and control (GNC) strategies for spacecraft formation flying.

• ZDPS-2 is the latest Nano-satellite mission of Microsat Research Center, Zhejiang University. It constitutes an in-orbit test platform for formation flying technology with two identical nano-satellites, ZDPS-2A and ZDPS-2B.

• The main objectives of ZDPS-2 mission are to demonstrate advanced guidance, navigation and control algorithms for formation flying; in-orbit performance test of self-designed ammonia micro-propulsion system; validate the precision of the S-Band Inter-Satellite Pseudo-Noise (PN) code ranging system; to validate the dual-frequency GPS receiver and the relative orbit determination algorithm; and to validate the MEMS accelerometer in-orbit calibration algorithm.

• The main subsystems and components of the ZDPS-2 gained space heritage on the ZDPS-1A mission launched on September 22, 2010. Both ZDPS-2A and ZDPS-2B are 25 × 25 × 25 cm cube-shaped and weigh around 12 kg.

• The satellites are equipped with tri-junction Ga-As solar cells as the primary power, tiled on all six planes of the satellite body, which have a 26.8% theoretical efficiency, and a Li-ion battery pack of ten cells from Sanyo serves as the secondary power. The transceiver works under the Universal S-Band (USB) TTC system, enjoys uplink data rates of 2kbps and adjustable downlink data rates of 1kbps-64kbps.

• The on-board computer (OBC) is composed of multi-CPU with FPGA, providing a universal computing, storage, management platform for command execution, TT&C, attitude & orbit control, payloads, etc.

• Sub-degree level attitude measurement will be achieved through a 3-axis magnetometer, a 3-axis MEMS gyroscope, four-quadrant analog sun sensors mounted on six surfaces and a digital sun sensor.

• Attitude control utilizes a momentum wheel, installed on the pitch axis, to provide both momentum bias and reaction actuation for pitch attitude maneuver, and three orthogonally mounted magnetic coils provide active control torque for detumbling and three-axis stabilization, with pointing accuracy of better than 2° and steady precision 0.1°/s.

• In order to obtain an accurate absolute position and velocity measurement, ZDPS-2 carries two GPS receivers. A UNICORE dual-frequency GPS receiver provides single point positioning accuracy of 2m (RMS), with observational data updating rate up to 10Hz. A Zhejiang University developed GPS receiver provides absolute position accuracy of 2m and velocity of 0.2m/s. A dual-frequency GPS antenna is mounted on the face opposite to the ground (-Z plane).

• ZDPS-2A&B are each equipped with an S-Band inter-satellite communication transceiver to exchange position and velocity data, capable of providing data transmission rate of 8kbps and a maximum communication range of 5km. In addition, an S-Band PN code ranging system is designed to provide PN code rate of no more than 2Mcps and ranging accuracy of 4cm for 1Mcps code rate. It could support for multiple composite codes such as JPL1999, T2, T4 and so on.

• The satellites are both equipped with a propulsion system, either of them can be treated as chief or deputy. The system uses liquid ammonia as a propellant with ISP greater than 900Ns/kg. With the fuel mass of 0.318kg and the satellite mass of below 12 kg, the system can provide a total ΔV of 24m/s.

• Nine CAS-3 satellites were onboard. Originally named Chinese Amateur radio Satellite 3, six of these satellites have been renamed XW-2 Xiwang-2 (Hope-2), XW-2A through XW-2F. All XW-2 satellites were developed by DFH Satellite Co. Ltd and CAMSAT.

• Xiwang-2A (CAS-3A) features a 398 × 398 × 398 mm cubic body with body mounted solar cells and a mass of approximately 25 kg mass. It features a three-axis stabilization system. The micro-satellite will be used for atmospheric physics experiments and amateur radio missions.

• The amateur communications payload consists of U/V 20 kHz wide transponders with 145 MHz CW beacon and 19k2 GMSK AX25 telemetry downlinks. Two small satellites, XW-2E and XW-2F, will fly piggyback on top of XW-2A.

• Xiwang-2B (CAS-3B), Xiwang-2C (CAS-3C) and Xiwang-2D (CAS-3D) are a constellation of three identical Chinese micro-satellites that will be used for atmospheric physics experiments and amateur radio missions.

• The satellites are cubic bodies with dimensions of 246 × 246 × 246 mm with body mounted solar cells and a mass of approximately 10 kg mass. They feature a three-axis stabilization system. The amateur communications payload consists of U/V 20 kHz wide transponders with 145 MHz CW beacon and 19k2 GMSK AX25 telemetry downlinks.

• The XY-2 Xinjishu Yanzheng-2 will test two kinds of electric propulsion engines (electric propulsion Hall LHT-100 engine and a magnetic and electric propulsion Hall engine) developed by the China Aerospace Science and Technology Corporation. The satellite was developed by Shenzhen DFH and has a mass of 130 kg.

• Xiwang-2E (CAS-3E) and Xiwang-2F (CAS-3F) are two identical picosatellites that will fly piggyback on top of the XW 2A satellite. The small satellites will be used for amateur radio mission only. They have a cubic shape similar to a CubeSat-1U with dimensions 116 × 116 × 116 mm. The have a mass of approximately 1.5 kg mass each. The amateur communications payload consists of U/V 20 kHz wide transponders with 145 MHz CW beacon and 19k2 GMSK AX25 telemetry downlinks.

• Developed by Shenzhen Aerospace Dongfanghong HIT Satellite Ltd. and CAMSAT, the DCBB (CAS-3G) is a CubeSat-U for the University educational purposes.

• LilacSat-2 (CAS-3H) was developed by the Harbin Institute of Technology. This is a low-cost, nano-satellite for education, amateur radio communication and technology demonstration, providing hands-on experience for students who would not otherwise have the opportunity to build flight hardware for a space mission.

• The 11 kg satellite is a cube-shaped 20 × 20 × 20 cm object carrying four payloads: a thermal infrared camera; an SDR based multi-band receiver, for reception and decoding of signals from AIS, ADS-B, etc.; a V/U amateur radio SDR platform; and a FPGA software testing platform . It can be configured as an FM repeater or an APRS digipeater. It will also provide a VHF CW beacon and UHF 9k6 BPSK telemetry downlink; and an FPGA software testing platform.

• LilacSat-2 will operate on a 520 × 520 km altitude orbit with an inclination of 97° on a mission from 3 to 6 months long.

• NUDT-Phone-Sat (CAS-3I) was developed by the National University of Defense Technology and CAMSAT and is an experimental pico satellite based on smartphone technology. Its dimensions are 98 × 98 × 7 mm and has a weight of 100 g.

Situated in the Kelan County in the northwest part of the Shanxi Province, the Taiyuan Satellite Launch Center (TSLC) is also known by the Wuzhai designation. It is used mainly for polar launches (meteorological, Earth resources and scientific satellites).

• The launch center has two single-pad launch complexes, a launch area for the new Long March-6 rocket, a technical area for rocket and spacecraft preparations, a communications centre, a mission command and control centre, and a space tracking centre.

• The stages of the rocket were transported to the launch centre by railway and offloaded at a transit station south of the launch complex. They were then transported by road to the technical area for checkout procedures.

• The launch vehicles were assembled on the launch pad by using a crane at the top of the umbilical tower to hoist each stage of the vehicle in place. Satellites were airlifted to the Taiyuan Wusu Airport about 300km away and then transported to the centre by road.

• The TT&C Centre, also known as Lüliang Command Post, is headquartered in the city of Taiyuan, It has four subordinate radar tracking stations in Yangqu (Shanxi), Lishi (Shanxi), Yulin (Shaanxi), and Hancheng (Shaanxi).

@Martian2 @cirr