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In the near future, developed countries don't need cheap labors from developing countries. They have army of robots that can build anything, compete with personal customization in each product they made. You can choose, design and add personal touch in front of computer with internet access, robot will manufacture it for you and arrive in front of your house in just couple of hours later. The price is even cheaper than made by cheap labors in developing countries.

Developing country market will be massively flooded by developed countries products, that even cheaper, higher quality, better design and more functionality than locally made.
 
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小伙额头上“种”鼻子 生长9个月成活
A young man "grows" a nose on on his forehead after nine months

文章来源: 东南网 于 2013-09-25
Source: Southeast Network on 2013-09-25
http://www.wenxuecity.com/news

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经过近9个月的生长,鼻子“种植”成功
After nearly nine months of growth, the nose, the "planting" successful

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取划线处进行移植
Line sketched on the edges of the graft will be transplanted

种花种草很常见,但“种”鼻子你见过吗,而且还是在人的额头上“种”?

福建医科大学附属协和医院的医生就花了近9个月时间,为在车祸中毁了鼻子的泉州小伙小连(化名)种“活”了一个鼻子。

这个额头上“种”出的鼻子,鼻孔、鼻柱、鼻粘膜一应俱全,还有完好的血供。

据协和医院整形外科主任郭志辉主任医师介绍,这个漫长、复杂的鼻子整形手术叫“鼻预构术”,小连做的这种手术在全国鼻整形中尚无先例。

车祸夺走了帅小伙的鼻子 鼻中隔软骨因感染被溶解

22岁的泉州小伙小连,浓眉大眼,长相还挺帅气。但去年8月,他和父亲发生了一场车祸。

车祸中,小连的鼻子受了严重外伤,左侧鼻翼没了,鼻柱也被毁了一部分。经过及时治疗,小连的身体并没有什么大碍,但由于家庭经济等原因,他并没有立即进行鼻整形手术。

不过,后来的感染加重了鼻子的缺损程度,小连的鼻中隔软骨慢慢被溶解了,导致严重鼻中隔缺损。

车祸和感染导致小连的鼻子明显畸形,不仅外观受到影响,由于狭窄、残存鼻柱右移等多种问题引起的通气过敏、气喘等毛病也随之而来。

车祸后,为了掩饰鼻子的缺陷,小连就戴起了口罩,整个人也变得自卑和消沉起来。

今年年初,考虑再三,小连在跑了多家医院后,最终找上协和医院整形外科询问治疗方法。

医生在患者额头上“种”鼻子 取肋骨软骨再造鼻柱

经过仔细检查,全国鼻整形亚专科常委、协和医院整形外科主任郭志辉主任医师发现,小连的鼻子缺损,无法采用传统的鼻再造术进行修补。

同时,郭主任的治疗团队查阅了大量的文献资料,都没有找到适合小连这种情况的鼻子再造术法。由于没有先例可以参考,在50多年整形经验的积淀下,郭主任的团队想做一个大胆的挑战。

经过慎重评估后,郭主任给小连制定了鼻整形手术,打算在小连的额部“种植”一个预构鼻,等达到“移植”手术指征后再进行预构鼻的转移修补。该手术分七期进行,历时一年左右。

小连同意全力配合治疗,郭主任便开始了漫长的“种”鼻之旅。

第一期手术扩张额部皮肤,把皮肤扩张器植入额部的皮肤内,并定期注水使其逐渐膨胀,以促进额部皮肤扩张,为鼻部再造提供皮肤。

鼻部新皮肤长好就耗了3个多月。传统手术一般是在第一期手术后,就将额部新增长的皮肤以皮瓣的形式转移覆盖到鼻部,进行鼻部再造术。如果小连采用这种传统术法,由于鼻中隔严重受损,以后鼻子极易塌陷变形。

于是,第二步郭主任进行了软骨支架预构,取小连的肋骨软骨,进行了鼻柱(包括鼻中隔、鼻小柱)再造,当天耗时4个多小时,终于完成这个鼻支架预构手术。

如何养活这个软骨,让鼻中隔拥有完好的血供,这是决定手术成败的难点。而给鼻中隔提供血液循环的粘膜仅为薄薄的1毫米。可以想象手术之精细。

大约又过了3个月,人工制造的粘膜终于发挥作用“养活”了鼻中隔。接下来,就是两侧鼻孔的成形手术,先进行右侧鼻孔成形,然后是左侧鼻孔成形。

每一个环节步步紧扣,任何一个环节的失败,都将影响最后的效果,因此必须严密观察血供情况,其中大量应用了皮瓣、包膜瓣等技术。
在经历了近9个月时间后,小连额头上的鼻子终于“种植”成功了。

“种”的鼻子成活了 测完动脉走向就能移植

郭主任说,小连的鼻子经过生长,目前已达到了可以“移植”的手术指征。

接下来要进行预构鼻转移手术,难度并不大。不过,在转移手术前,还需要测定小连额部给鼻子提供血供的动脉—滑车动脉走向,然后确定具体的预构鼻转移方案。

最后的鼻子转移并不是整个进行移植,而是局部进行移植,取新长鼻子的下半部(如图),将这部分鼻子翻转覆盖在缺损的鼻部。翻转鼻子不可过分分离,还要与额部皮肤相连以获取血液供应,否则会影响转移鼻子的成活,因此选择在额部种鼻子的原因也在于此。

预构鼻转移手术在近期很快就能进行,预计手术时长为2.5-3个小时。

这个手术结束后,还要进行“断蒂手术”,顾名思义,即通过鼻子周围血供可以“养活”转移的鼻子后,就可以断掉移植鼻子与额部之间的血供连接,多余皮肤仍铺回原来额部缝合。

最后一步,就是进行“微雕”,让鼻子更加自然。至此,一个完美的鼻部再造手术就完成了。

小连说,最近他的心情已经越来越急迫了。正常的鼻子缺损了,额头又长了一个“鼻子”,这让他每次出门都要全副武装,口罩、棒球帽这样的装备一样都不能少。“希望手术快点结束,我能快点甩掉口罩,恢复自由呼吸。”

郭主任说,鼻子再造的整形理念其实由来已久,早在1998年,从事组织工程医学研究的专家就探索“老鼠背上长人耳朵”。而鼻预构术是在传统理念方法上的再创新,这样的鼻整形手术在国内尚属首例。经过此次的摸索,下个病人进行鼻预构术直接分三步就能完成了。

福州新闻网讯 随着科技的进步,培育人造器官已不再是一个梦想。近日,福建医科大学附属协和医院为因车祸鼻子受伤腐烂的患者在额头上培育出一个人造鼻子,如果一切顺利进行,下一步,这个人造鼻子将从额头上取下,而后移植到患者面部。据悉,在额头上进行鼻预构手术在国内尚属首例。

去年8月,泉州小伙小连(化名)遭遇车祸鼻子受伤,起先以为只是小伤,并没有放在心上,最终导致鼻子慢慢腐烂。今年初,在家人的劝说下,小连决定来到福建医科大学附属协和医院做整形手术。

24日,记者在福建医科大学附属协和医院见到了小连的主治医生郭志辉。据郭医生介绍,小连因鼻中隔缺损,医院无法应用传统的方法进行鼻再造手术,经讨论,决定进行鼻预构手术。

郭医生表示,鼻预构手术就像是在患者的额头上“种”出一个新的鼻子来,“等到这个鼻子长好以后,再通过移植手术将培育出来的鼻子代替原来受损的鼻子。”

经过几个月的治疗,目前手术已完成4个主要步骤,包括额部皮肤扩张、软骨支架预构和左右两侧鼻孔成型。“这个手术已经成功完成了80%,剩下的预构转移、断蒂、微雕,三个步骤是我们经常做的手术,没有难度。”郭医生说。

记者了解到,在额头进行鼻预构手术在国内尚属首例。另据外媒报道,今年初,英国伦敦大学学院的科学家曾在一名因皮肤癌失去鼻子的男性患者手臂上培育出一个人造鼻子并移植到其面部。




Flowers and grass are common, but the " kind " nose you seen it , but also in people 's forehead "species" ?

Union Hospital of Fujian Medical doctors spent nearly nine months time, as in a car accident ruined nose Quanzhou guy even a small ( a pseudonym ) kind of "live" a nose.

The forehead "kind of" out of the nose , nostrils, nasal column , nasal readily available, there intact blood supply .

According to Union Hospital, director of plastic surgery Kwok chief physician , this lengthy , complex nose plastic surgery called " prefabricated nose surgery " , small even in the country to do this surgery Rhinoplasty is no precedent .

Accident took handsome nose septal cartilage is dissolved due to infection

22 -year-old guy Quanzhou small even , thick eyebrows , looks quite handsome. But last August , he and his father had a car accident .

Car accident , even a small nose suffered serious injuries, the left nose is gone, also destroyed part of the nasal column . After timely treatment , even a small body and no serious problem , but because of family economic and other reasons, he did not immediately rhinoplasty .

However, the subsequent infection of the nose increased deficit , even a small septal cartilage slowly being dissolved , resulting in severe septal defect .

Accidents and infections lead to even a small nose obvious deformity, only the appearance of affected due to narrow right column remnants of nasal ventilation and other problems caused by allergies , asthma and other illnesses also follow.

After the accident , in order to cover the nose defects even on the DAI Qi small masks , the people have become self-esteem and depression together .

Earlier this year, think twice, even a small number of hospitals in the run , the final look on Plastic Surgery , Union Hospital, asking treatment.

Doctors on the forehead of the patient , " graft " to take rib cartilage nose reconstruction columella

After careful examination , the Standing Committee of the National nose surgery subspecialties , Union Hospital, director of plastic surgery Kwok chief physician found that even a small defect on the nose , you can not use the traditional nasal reconstruction surgery to repair .

Meanwhile, Director Guo 's treatment team access to a large number of documents , did not find even this situation for small nose reconstruction method . Since there is no precedent can refer to the accumulation of 50 years of experience in plastic surgery , the Director Guo 's team wanted a bold challenge.

After careful evaluation, Director Guo give small even developed rhinoplasty , intended connection in a small forehead " planting " a prefabricated nose, etc. to achieve "transplanted" indications for surgery performed after the transfer of prefabricated nose repair. The surgery in seven phases, which lasted about a year .

Small even agreed to fully cooperate with treatment, Director Guo began a lengthy "species" nose trip.

The first phase of expansion of the forehead skin surgery , the tissue expander implanted inside the skin of the forehead , and regular water it gradually expanded to facilitate the forehead skin expansion for nasal reconstruction provides the skin.

Nasal new skin grows well on the consumption of more than three months. Traditional surgery is generally in the first period after surgery , it will be a new growth forehead flap of skin in the form of transfers to cover the nose for nasal reconstruction . Even if the small traditional technique using this method , since the nasal septum severely damaged after the collapse easily deformed nose .

Thus , the second step Director Guo were prefabricated cartilage , even take a small rib cartilage for nasal column ( including the nasal septum , nasal columella ) recycling , the day took more than four hours , and finally completed the nasal stents prefabricated surgery.

How to feed the cartilage , so that the nasal septum has a good blood supply, which is to determine the success of surgery difficult . The blood circulation to the nasal mucosa provides only a thin 1 mm . Imagine surgery fine .

Then, after about three months, the artificial mucosa finally play " feed " the nasal septum . Next, the forming operation is both nostrils , the first for forming the right nostril , the left nostril and shape.

Every aspect of every step closely , any link failure will affect the final results, it is necessary to closely observe the blood supply , including a large number of applications flap envelope flap techniques.

After nearly nine months , a small nose and finally even his forehead , " planting " a success.

"Species" survival of the nose to be able to test finished arterial graft

Director Guo said that the small nose even after growth has now reached that can be "transplanted" indications for surgery .

Next step is to carry out the transfer of prefabricated nasal surgery , the difficulty is not great. However, the transfer before surgery , you also need to determine even a small nose and forehead provide arterial blood supply - arteries to tackle , and then determine the specific transfer programs prefabricated nose .

The final transfer of the nose is not the whole transplant , but the partial transplant , take the lower half of the new long nose ( Figure ) , this part of the nose, nasal flip cover the defect . Flip nose not too isolated , but also connected with the forehead skin to get the blood supply , otherwise it will affect the survival of the transfer nose , so choose the kind of nose, forehead reason also here.

Transfer of prefabricated nasal surgery can be carried out quickly in the near future , it is expected surgery duration of 2.5 to 3 hours.

After this surgery , but also for " pedicle operation" , by definition, that is, through the blood supply around the nose can " feed " the transfer of the nose , you can cut off the nose and the forehead between the transplanted blood supply connection , the excess skin is still Shop back to the original frontal suture.

The final step is a " miniature ", so that the nose more natural. Thus, a perfect nose reconstruction surgery is complete.

Small even said that recently his mood has become increasingly urgent. Defect in the normal nose , forehead and long a "nose" , which makes him out to be armed each , masks, baseball caps such equipment like Less . "I hope the surgery end quickly , I was able to quickly get rid of the mask to restore free breathing ."

Director Guo said , nose plastic recycling concept is actually a long time , back in 1998 , engaged in medical research tissue engineering experts to explore the "mouse ears back, big man ." The prefabricated nasal surgery in the traditional concept of methodological re-innovation, such as rhinoplasty first in the country . After this exploration, the next patient prefabricated nasal surgery can be done in three steps directly .

Fuzhou News Network With advances in technology , foster artificial organs is no longer a dream. Recently, Union Hospital of Fujian Medical University, nose injured in a car accident on his forehead were rotting breed an artificial nose, and if all goes well for the next step, this artificial nose is removed from the forehead , and then transplanted to the patient's face . It is reported that the nose on the forehead prefabricated surgery first in the country .

Last August, Quanzhou little guy even ( a pseudonym ) had an accident and injured his nose , at first thought it was only minor injuries and did not mind, eventually leading to the nose slowly decaying . Earlier this year, persuaded his family , small even decided to come to Union Hospital of Fujian Medical University to do plastic surgery.

On the 24th , the reporter in Union Hospital of Fujian Medical University, saw the little doctor Kwok connected . According to Guo doctors, even a small septal defect because the hospital can not apply traditional methods nasal reconstruction surgery , after discussion , decided to conduct prefabricated nasal surgery.

Dr. Guo said prefabricated nose surgery is like the patient's forehead "kind of" a new nose , the " wait until well after the long nose , and then out through the transplant surgery will foster the nose instead of the original damaged nose. "

After several months of treatment, the current operation has completed four major steps, including the forehead skin expansion , prefabricated cartilage left and right sides of the nose shape. "This operation has been successfully completed 80 % of the remaining prefabricated transfer pedicle , miniature , three steps that we often do the surgery , there is no difficulty ." Dr. Guo said.

Reporters learned that, in the forehead for prefabricated nose surgery first in the country . According to foreign media reports earlier this year, scientists at University College London, worked in a losing cause skin cancer in men with arm nose breed an artificial nose and migrate to their face.


net assisted translation


Fujian University - Union Hospital

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The '50-50' Chip: Memory Device of the Future? Material Built from Aluminum and Antimony Shows Promise for Next-Generation Data-Storage Devices

The '50-50' chip: Memory device of the future? Material built from aluminum and antimony shows promise for next-generation data-storage devices

Sep. 13, 2013 — A new, environmentally-friendly electronic alloy consisting of 50 aluminum atoms bound to 50 atoms of antimony may be promising for building next-generation "phase-change" memory devices, which may be the data-storage technology of the future, according to a new paper published in the journal Applied Physics Letters, which is produced by AIP Publishing.

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Phase-change memory arrays. (Credit: AIP)

Abstract:


Phase-change memory is being actively pursued as an alternative to the ubiquitous flash memory for data storage applications, because flash memory is limited in its storage density and phase-change memory can operate much faster.

Phase-change memory relies on materials that change from a disordered, amorphous structure to a crystalline structure when an electrical pulse is applied. The material has high electrical resistance in its amorphous state and low resistance in its crystalline state -- corresponding to the 1 and 0 states of binary data.

Flash memory has problems when devices get smaller than 20 nanometers. But a phase-change memory device can be less than 10 nanometers -- allowing more memory to be squeezed into tinier spaces. "That's the most important feature of this kind of memory," said Xilin Zhou of the Shanghai Institute of Microsystem and Information Technology at the Chinese Academy of Sciences. Data can also be written into phase-change memories very quickly and the devices would be relatively inexpensive, he added.

So far, the most popular material for phase-change memory devices contains germanium, antimony, and tellurium. But compounds with three elements are more difficult to work with, Zhou said.

It's difficult to control the phase-change memory manufacturing process of ternary alloys such as the traditionally used germanium-antimony-tellurium material. Etching and polishing of the material with chalcogens can change the material's composition, due to the motion of the tellurium atoms, explained Zhou.

Zhou and his colleagues turned to a material with just two elements: aluminum and antimony. They studied the material's phase-changing properties, finding that it's more thermally stable than the Ge-Sb-Te compound. The researchers discovered that Al50Sb50, in particular, has three distinct levels of resistance -- and thus the ability to store three bits of data in a single memory cell, instead of just two. This suggests that this material can be used for multilevel data storage.

A two-step resistance drop during the crystallization of the material can be used for multilevel data storage (MLS) and, interestingly, three distinct resistance levels are achieved in the phase-change memory cells, Zhou says. "So the aluminum-antimony material looks promising for use in high-density nonvolatile memory applications because of its good thermal stability and MLS capacity."

The researchers are now investigating the endurance or reversible electrical switching of the phase-change memory cell with MLS capacity.

Also read:

Phase transition characteristics of Al-Sb phase change materials for phase change memory application | Browse - Applied Physics Letters

Phase transition characteristics of Al-Sb phase change materials for phase change memory application


Authors and affiliations:

Xilin Zhou-1,2, Liangcai Wu-1, Zhitang Song-1, Feng Rao-1, Kun Ren-1,2, Cheng Peng-1, Sannian Song-1, Bo Liu-1, Ling Xu-3, and Songlin Feng-1

1- Shanghai Key Laboratory of Nanofabrication Technology for Memory, Shanghai Institute of Micro-system and Information Technology, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China

2- University of Chinese Academy of Sciences, Beijing 100080, People's Republic of China

3- National Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, People's Republic of China



中国科学院上海微系统与信息技术研究所纳米技术实验室
Shanghai Key Laboratory of Nanofabrication Technology for Memory, Shanghai Institute of Micro-system and Information Technology, Chinese Academy of Sciences


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嘉定园区 Jiading Campus

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长宁园区 Changning Campus

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中国科学院大学
University of Chinese Academy of Sciences


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Changchun Campus

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Shanghai Campus

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Center for Earth Observation and Digital Earth (CEODE), CAS, Beijing

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Ningbo Campus

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Guangzhou Campus

南京大学 Nanjing University


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China to launch satellite in search of dark matter

xinhuanet.com
English.news.cn 2013-09-25 14:09:13

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BEIJING, Sept. 25 (Xinhua) -- China's top scientific research institute is in the process of developing five space research satellites, including one for the detection of dark matter particles.

We expect to launch at least three to four of them before 2015, said Bai Chunli, president of the Chinese Academy of Sciences (CAS) at the first meeting of the academy's newly founded advisory committee in Beijing Tuesday.

The other four satellites include one for the conduct of quantum science experiments, an X ray telescope, a retrievable scientific study satellite and a solar activity study satellite, Bai said.



Does dark matter exist in our sun’s neighborhood?
By Deborah Byrd in
SPACE on Sep 05, 2012

Link

Astronomers have grown convinced over decades that dark matter exists on the large scale of our universe. But what about our neighborhood of space?

In the 1930s, astronomers began to suspect that clusters of galaxies in our universe must be filled with a mysterious dark matter that kept the galaxy clusters from flying apart. This dark matter can’t be seen, even with telescopes. It doesn’t emit light. It doesn’t absorb light. But since the 1930s, astronomers have come to use the idea of dark matter to account for a large part of the total mass of the universe.

But what about our local area of space – the immediate vicinity in the neighborhood of our sun? Do astronomers know of dark matter that exists nearby?


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Credit: es-static.us
Astronomers use the idea of dark matter to account for a substantial portion of the mass of our universe. An even greater amount of mass, they believe, is taken up with dark energy. Meanwhile, the visible stars and galaxies we see around us in space may be only a small part of the whole universe. Image via Wikimedia Commons.

When we speak of dark matter, we’re often speaking on a grand scale – the scale of our galaxy at least – and often the scale of the whole universe. But experts have been less sure how much dark matter there is in the neighborhood of our own Earth and sun. However, in 2012, European and Chinese astronomers said they found large amounts of dark matter near our sun.

These astronomers developed a new way of measuring mass. They tested their technique first on a state-of-the-art simulation of our galaxy. The results suggested that, in the past, scientists have been underestimating the amount of dark matter in space. So the team adjusted their technique – and then applied it to real data – in this case, the known positions and velocities of thousands of orange dwarf stars near our sun.

Their work showed that dark matter almost definitely does exist – invisibly – in our sun’s vicinity.

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Credit: es-static.us
Strong gravitational lensing as observed by the Hubble Space Telescope in Abell 1689 indicates the presence of dark matter. This is just one piece of evidence – among many collected over decades – that dark matter exists on the large scale of our universe. Image via Wikipedia.

Bottom line: Astronomers have grown convinced over decades that dark matter exists on the large scale of our galaxy and universe. In 2012, astronomers in Europe and China found evidence for dark matter in the space near our sun.


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A missing link to our past - 419 million years ago?

古脊椎所等4亿多年前古老鱼类化石的研究揭开有颌脊椎动物的演化史
2013-9-26
www.ivpp.cas.cn_Chinese Text

从大白鲨到人类,长着上下嘴巴的脊椎动物被称为有颌类,占现生脊椎动物物种数的99.7%。有颌类包括四大类群:盾皮鱼纲、棘鱼纲、硬骨鱼纲和软骨鱼纲,其中前两个纲业已全部灭绝。搞清楚这些大支系之间的亲缘关系,特别是弄清作为陆生脊椎动物乃至人类直系祖先的硬骨鱼类的起源,硬骨鱼纲和软骨鱼纲共同祖先的特征组合,是重建有颌类演化之树的关键。9月25日英国《自然》杂志在线报道了中国科学院古脊椎动物与古人类研究所朱敏研究员领导的国际古生物学家团队在早期脊椎动物演化方面取得的最新进展。朱敏等人在中国云南省古老的志留纪地层中发现了一条保存完好的古鱼,并将其命名为“初始全颌鱼(Entelognathus primordialis)”。

这条鱼虽然在其他方面都保持着盾皮鱼纲(最原始的有颌脊椎动物)的身体形态,但却已经演化出硬骨鱼纲(亦称硬骨脊椎动物,包括陆生脊椎动物和仍生活在水中的硬骨鱼类)的典型颌部结构或面部特征,是古生物学家梦寐以求的,介于这两大类群之间的“缺失环节”,它在古生物学上的重要意义,类似于始祖鸟、游走鲸和南方古猿等耳熟能详的“过渡化石”。

过去,科学家对早期有颌类的了解主要集中在泥盆纪,因为有颌类的化石记录直到这个时代才变得丰富起来,泥盆纪也因此被称为“鱼类时代”。然而,从泥盆纪一开始,有颌类四大类群不仅已经全部演化出来,而且彼此形态已经极为不同。仅仅凭借泥盆纪的化石证据,没有介于各主要类群之间的过渡化石,是无法确切地了解它们是如何演化而来的。然而,在更古老的志留纪有颌类留下的化石少得可怜,长期以来,科学家只能依靠显微镜下才能看到的鳞片,细小的牙齿或一点点骨头碎片,“盲人摸象”式地猜测志留纪有颌类的模样。有颌脊椎动物的早期历史笼罩在迷雾之中。

新发现的全颌鱼生活在距今4.2亿年前冈瓦纳大陆北缘的近岸水域中,体长约30厘米,身体扁平,靠着在水底笨拙地游来游去,搜寻柔软的食物,如藻类、水母和生物碎屑等等为生。它生活的环境中已经存在相当大的掠食者,全颌鱼必须小心翼翼地避开它们。粗粗看去,很容易认为全颌鱼是盾皮鱼类,特别是后来在泥盆纪十分繁盛的节甲鱼类的一份子。它们的前半身同样都包裹在大块骨片拼成的铠甲中,这套护身铠甲由箱形的躯甲和包覆头部的头甲组成,两者之间由一颈关节相连,以便头可以向上抬起。就连骨片的形状和排列方式,全颌鱼和典型的节甲鱼类之间也只有细微的差别。然而,如果把全颌鱼翻过来,仔细观察一下它的颌部,就会立即认识到它不同于任何节甲鱼,也不同于以往发现的任何盾皮鱼类,因为它具有硬骨鱼类才有的典型颌部结构或面部特征,即有着一张硬骨鱼类才有的嘴巴!

脊椎动物的骨骼可分为内外两大骨骼系统。最原始的颌由无颌脊椎动物的鳃弓演化而来。原始的上颌骨称为腭方软骨,下颌骨称为麦氏软骨,它们都属于内骨骼系统,其简单的构造不能完全胜任咬合、剪切和研磨等等功能。因此,随着有颌脊椎动物的演化,属于外骨骼系统的骨头不断被整合入颌部结构,使得颌更坚固,更灵活,适应多种多样的需要。外骨骼介入颌部结构的模式,是有颌类四大类群间的根本区别之一。

原始硬骨鱼类复杂的外骨骼颌部与其他三大类有颌脊椎动物都很不一样,这让试图追溯硬骨鱼类起源的古生物学家很是挠头。因为盾皮鱼的上颌片和下颌片都位于口缘内侧,只相当于硬骨鱼类内侧那些不太重要的骨片(犁骨、冠状骨等),而构成硬骨鱼颌最主要的成分——前上颌骨、上颌骨、齿骨等口缘骨片,仿佛是凭空出现一般,在盾皮鱼中找不到任何对应。鉴于此,科学家们长期以来认为前上颌骨、上颌骨和齿骨这些颌部骨骼是在硬骨鱼纲这一演化支系中新生的。然而,全颌鱼的发现改变了这一切,过去认为硬骨鱼纲独有的颌部特征,在盾皮鱼纲的某些类群中早已演化出来了。

据朱敏研究员介绍,“基于现有证据,特别是全颌鱼所提供的全新信息,我们使用被称为分支系统分析的方法,对大量早期有颌脊椎动物进行了综合研究,提出了最新的有颌类演化谱系。在这一谱系中,盾皮鱼类被确证不再是一个单系或自然类群,而只是一系列较原始有颌脊椎动物的集合,而除盾皮鱼类外的所有有颌脊椎动物,却很有可能拥有共同的祖先,从而构成一个单系类群。全颌鱼跟硬骨鱼纲与软骨鱼纲的共同祖先很有可能长得差不多”。

全颌鱼的发现实际上告诉我们,有颌脊椎动物的共同祖先向两个方向发展:一支保留并改进了盾皮鱼类的大型外骨骼骨片,这就是硬骨鱼类;另一支则丢失了大型外骨骼,代之以细小的鳞片和小块骨片,其中较原始的类群构成棘鱼,而软骨鱼类是由棘鱼中的一支演化而来。

此项研究获得了国家自然科学基金委员会、国家重点基础研究发展规划项目和中国科学院的大力支持。




Exceptionally-preserved Fossil Fish From China Reveals the Evolution of Early Jawed Vertebrates
Update time: 09/26/2013

Exceptionally-preserved Fossil Fish From China Reveals the Evolution of Early Jawed Vertebrates----Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences

The evolution of jaws is one of the key episodes in the evolution of vertebrates, but the gap between jawed and jawless vertebrates is so large that it is hard to work out the individual evolutionary steps in the transition. An international team led by Dr. ZHU Min, Institute of Vertebrate Paleontology and Paleoanthropology (IVPP), Chinese Academy of Sciences, reported an exceptionally well-preserved 419-million-year-old fish from Qujing, Yunnan in China that is the most primitive vertebrate to have a modern type of jaw.

This fish is a placoderm, one of a member of an extinct group of gnathostomes (jawed vertebrates), named Entelognathus primordialis, but its jaw is much more like that of a modern bony fish. The finding published online September 25 in Nature provides compelling evidence for the evolutionary link between placoderms and osteichthyans, and adjusts our understanding of early gnathostome evolution.

The holotype of Entelognathus primordialis represents a three-dimensionally preserved fish with articulated head shield and trunk armour, approximately 11 cm long, suggesting a total body length of over 20 cm. It was unearthed from the Late Silurian (Late Ludlow, 419 million years ago) Kuanti Formation at the Xiaoxiang Reservoir near Qujing City of Yunnan Province in China.

Entelognathus is a placoderm, an extinct grade of primitive armoured fishes. All other placoderms discovered up to this point have had simple jaws and cheeks, with the outer surfaces composed of only a few large bones. Entelognathus on the other hand has a more complex arrangement of smaller bones, including a premaxilla and maxilla lining the upper jaw and a dentary on the lower jaw plus cheek bones comprising a jugal and lacrimal.

This is the same arrangement found in modern bone-bearing vertebrates including most fishes and all tetrapods, the limbed vertebrates including humans.

Besides osteichthyans, the other living gnathostomes are the chondrichthyans, a group including sharks and rays. These have almost no bone in their bodies and have skeletons made of cartilage. Until very recently it was widely accepted that this condition represented the primitive state among the living jawed vertebrates.

In other words, the most recent common ancestor of all gnathostomes would have looked something like a shark, devoid of armor and with a largely cartilaginous skull and skeleton. While both osteichthyans and placoderms have skulls made of large plates, it was widely assumed that the two groups were not related. Thus the immediate ancestors of osteichthyans would have acquired their bony skulls from scratch. It was even suggested that the jaws of placoderms evolved independently of other gnathostomes.

This astounding discovery may offer a new perspective on the early evolution of these creatures. Osteichthyans did not independently acquire their bony skeletons, they simply inherited them from placoderm ancestors. At the same time, the lineage that led to chondrichthyans progressively lost their bony skeletons. Modern jawed vertebrates, such as sharks and bony fishes, emerge from a collection of jawed, armoured fishes known as placoderms.

The holotype specimen of Entelognathus was found in 2010, however a majority of the specimen was buried in the matrix in the field. Before its preparation in the laboratory, we had not paid special attention to this specimen, said Dr. ZHU Min of the IVPP, lead author and project designer, "The careful lab work in 2011 unveiled its superb preservation for a compelling evidence of an osteichthyan-like marginal jaw bones in a placoderm. If the jaws of Entelognathus were not articulated with the skull and trunk armour (as many specimens from the same horizon), we probably assign them to an osteichthyan fish".

This work was mainly supported by the Major State Basic Research Projects of MST of China, and the National Natural Science Foundation of China.





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图1初始全颌鱼(Entelognathus primordialis)化石,a前侧视,b侧视,c前腹视,d背视,c 复原图。(朱敏供图)
Fig.1 Holotype of Entelognathus primordialis gen. et sp. nov., a 419-million-year-old jawed fish with head and trunk armour from the Kuanti Formation of Qujing, Yunnan, China, in anterolateral (a), lateral (b), anteroventral (c) and dorsal (d) views. Scale bars, 1 cm. e, Life restoration. (Image by ZHU Min)



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图2初始全颌鱼(Entelognathus primordialis)生态复原图(Brian Choo 供图)
Fig.2 Life restoration of Entelognathus primordialis. (Image by Brian Choo)



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图3 有颌脊椎动物演化谱系图(ZHU min, Brian Choo 供图)
Fig.3 The progression of jawed vertebrate skull (Image by ZHU Min, Brian Choo)




Also read:

Entelognathus: Paleontologists Find 419-Million-Year-Old Jawed Fish
Sep 26, 2013 by Sergio Prostak

Entelognathus: Paleontologists Find 419-Million-Year-Old Jawed Fish | Paleontology | Sci-News.com

A team of paleontologists from China, the United States and Sweden has found a well-preserved fossil of ancient fish that lived in what is now China about 419 million years ago during the Late Silurian period


The fossil has been collected from the Kuanti Formation near Qujing City, Yunnan Province.

The fish, named Entelognathus primordialis, was a 20-cm-long placoderm – an extinct class of armor-plated fishes, the first known animals to evolve true jaws.

Like other placoderms, Entelognathus had armored plates, but it also had more advanced jaw bones – features previously seen only in Osteichthyes (bony fishes).

“The holotype specimen of Entelognathus was found in 2010, however a majority of the specimen was buried in the matrix in the field,” explained Dr Min Zhu from the Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, who is a lead author of the paper reporting the discovery in the journal Nature.

image_1412_2-Entelognathus.jpg


Top: a three-dimensionally preserved specimen of Entelognathus primordialis with head and trunk armor in lateral view. Scale bar – 1 cm. Bottom: life restoration of Entelognathus primordialis. Image credit: Min Zhu et al.

“Before its preparation in the laboratory, we had not paid special attention to this specimen.”

Dr Zhu added that the careful lab work in 2011 unveiled its superb preservation for a compelling evidence of an osteichthyan-like marginal jaw bones in a placoderm.

“If the jaws of Entelognathus were not articulated with the skull and trunk armor as many specimens from the same horizon, we probably assign them to an osteichthyan fish.”

According to the paleontologists, the discovery of Entelognathus provides evidence for the evolutionary link between placoderms and bony fishes, and adjusts the understanding of early evolution of gnathostomes (jawed vertebrates).

______

Bibliographic information: Min Zhu et al. A Silurian placoderm with osteichthyan-like marginal jaw bones. Nature, published online September 25, 2013; doi: 10.1038/nature12617






A Silurian placoderm with osteichthyan-like marginal jaw bones
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12617.html#affil-auth
Published online 25 September 2013



Authors and Affiliations

Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China
Min Zhu, Xiaobo Yu, Brian Choo, Jing Lu, Tuo Qiao, Wenjin Zhao, Liantao Jia & You’an Zhu


Department of Biological Sciences, Kean University, Union, New Jersey 07083, USA
Xiaobo Yu

Subdepartment of Evolution and Development, Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Uppsala 752 36, Sweden
Per Erik Ahlberg, Qingming Qu & Henning Blom

Abstract

The gnathostome (jawed vertebrate) crown group comprises two extant clades with contrasting character complements. Notably, Chondrichthyes (cartilaginous fish) lack the large dermal bones that characterize Osteichthyes (bony fish and tetrapods).

The polarities of these differences, and the morphology of the last common ancestor of crown gnathostomes, are the subject of continuing debate. Here we describe a three-dimensionally preserved 419-million-year-old placoderm fish from the Silurian of China that represents the first stem gnathostome with dermal marginal jaw bones (premaxilla, maxilla and dentary), features previously restricted to Osteichthyes.

A phylogenetic analysis places the new form near the top of the gnathostome stem group but does not fully resolve its relationships to other placoderms. The analysis also assigns all acanthodians to the chondrichthyan stem group. These results suggest that the last common ancestor of Chondrichthyes and Osteichthyes had a macromeric dermal skeleton, and provide a new framework for studying crown gnathostome divergence.



See the 3-D visual images here
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12617.html#videos


中国科学院脊椎动物进化系统学重点实验室
Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China

中国科学院古脊椎动物与古人类研究所
Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences


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中国古动物馆 The Paleozoological Museum of China (PMC)
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Paleozoological Museum of China
 
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Leaps and bounce. Leaps and bounce. I tell you.

I dare say China has arrived at a critical point (like critical mass in a nuke bomb) in advances. There is no going back.
 
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In the near future, developed countries don't need cheap labors from developing countries. They have army of robots that can build anything, compete with personal customization in each product they made. You can choose, design and add personal touch in front of computer with internet access, robot will manufacture it for you and arrive in front of your house in just couple of hours later. The price is even cheaper than made by cheap labors in developing countries.

Developing country market will be massively flooded by developed countries products, that even cheaper, higher quality, better design and more functionality than locally made.

What will humans do then
I prefer to keep a human in the loop & by soon how much soon you are talking about
I think atleast 4-5 decades when robots will build every thing
 
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What will humans do then
I prefer to keep a human in the loop & by soon how much soon you are talking about
I think atleast 4-5 decades when robots will build every thing

Human will adapt into the new situation in the future.

Robot will change the world, probably sooner than most people expected. As developed countries are having an economy crisis from the cheap Made in China goods. The only solution for them to keep compete with China is to embrace third industrial revolution. Taiwan is preparing for that too, as Chinese labors are getting expensive.

After China, there will be no outsourcing manufacture to third world country trend in massive way anymore.
 
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全球首个“人工角膜”产品已成功完成
The world's first "artificial cornea" products have been successfully completed


2013-9-30

http://www.bioon.com

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Credit: instrument.com.cn

全球首个“人工角膜”产品已由深圳艾尼尔角膜工程公司成功完成。多中心临床试验情况显示,“人工角膜”的愈后效果已经接近人体角膜。

9月29日,由我国著名眼科专家北京同仁医院邹留河教授主持的“人工角膜”的临床试验总结会议在深圳召开。该“人工角膜”的临床试验由国内著名的眼科临床医院担任临床试验工作,以北京同仁医院牵头,由四川大学华西医院、河南眼科中心、武汉协和医院等医院参与。多中心临床试验数据显示,总有效率超过了90%;经过临床试验观察,“人工角膜”的愈后效果已经接近人体角膜。

据悉,该项重大的科研成果,在国家“863计划”支持下,已由中国生物医学再生科技有限公司(08158.HK)下属子公司深圳艾尼尔角膜工程有限公司,与第四军医大学组织工程研发中心金岩教授的团队联合开发成功,并投资建成了产业化的规模生产基地。该产品是组织工程的前沿产品,可以替代人捐献角膜,这是目前世界上第一个也是唯一一个完成临床试验的高科技人工角膜产品,该产品完全由我国科学家自主研发并拥有完整的自主知识产权。

角膜是眼球前部的一层高度透明的组织,就像照相机的镜头一样对成像起了关键作用,一旦混浊或受损将直接导致患者失明。目前,患者重见光明的唯一办法是移植捐献获得的异体人角膜,但是,目前全国人捐献角膜每年仅3000例,而全国需要移植的角膜病患者超过了500万,每年还新增10多万患者,由此可见由于捐献角膜的严重缺乏,又没有替代产品,致使角膜病人的医治问题长期无法解决。

据悉,当天参加“人工角膜”临床总结大会的专家和眼科医师高度认定了“人工角膜”的临床效果。业内人士指出,该产品将极大地解决角膜供体不足的问题,有望成为一个造福人类的革命性眼科产品。(生物谷Bioon.com)


The world's first "artificial cornea " products from Shenzhen Anil Cornea Engineering Company successfully completed. Multi-center clinical trial indications "artificial cornea ," the effect is already close to the body after healing cornea .

September 29 , by the famous ophthalmologist Beijing Tongren Hospital, Professor Zou Liuhe auspices of " artificial cornea " clinical trials wrap-up meeting was held in Shenzhen . The "artificial cornea ," the clinical trial was conducted by a renowned clinical ophthalmology hospital as a clinical trial work to Beijing Tongren Hospital , led by the West China Hospital , Sichuan University , Henan Eye Center , Wuhan Union Hospital and other hospitals to participate. Multi-center clinical trial data show that the total efficiency of more than 90% ; been observed in clinical trials , "artificial cornea ," the effect is already close to the body after healing cornea .

It is reported that the major scientific research in the national " 863 Program" , supported by China Bio-Med Regeneration Technology Limited (08158.HK) subsidiary Shenzhen Anil Cornea Engineering Company Limited, with the Fourth Military Medical University Organization Engineering R & D Center Professor Jin Yan joint development team success, and investment into industrial -scale production base. The product is the forefront of tissue engineering products , can replace human donor cornea , which is the world 's first and only one to complete clinical trials of high-tech artificial cornea product that completely independently developed by the Chinese scientists have complete independent intellectual property rights .

The cornea is the eye 's front layer of highly transparent organization , like a camera lens as the imaging plays a key role , if cloudy or damaged will directly lead to blindness . Currently, patients see again the only way to get the allogeneic transplant donated human cornea, however , the current national human donor corneas only 3,000 cases per year , while the national need corneal transplants in patients with more than 5 million , has added more than 10 million per year patients can be seen as a serious lack of donor cornea , and no alternative products , resulting in the patient's treatment of the cornea can not solve the problem long term .

It is learned that day to participate in "artificial cornea ," concluded the General Assembly of clinical specialists and ophthalmologists highly identified "artificial cornea " clinical results. Insiders pointed out that the product will greatly solve the problem of insufficient donor cornea , is expected to become a revolutionary ophthalmic products for the benefit of mankind . ( Bio Valley Bioon.com)

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