By mid to late 21st century, relations between Pakistan and KSA are likely going to become colder. Pakistan's economy is quickly growing, as is its population, which will likely lead to Pakistan asserting itself far more deeply, in the Muslim world. This will no doubt lead to Pakistan and KSA butting heads, as both compete to lead the Sunni Muslim world.
Likewise, Pakistan's relations with Turkey and Iran are also may become difficult, for likely the same reasons, as the later two also are trying to become the undeclared leaders of the middle east and the Muslim world, as a whole.
With KSA, it will be very difficult to avoid such an eventuality, if not down right impossible; Shared historical geopolitical and military cooperation, and culture will likely delay any sort of degradation of ties, but it will be unlikely to stop such an occurrence from happening. With Turkey and Iran, things will be easier, but Pakistan will have to build and define its relationship with both the Turks and the Persians now. With Turkey, Pakistan has the benefit that it won't have to directly compete with them, as both are geographically far apart, with similar noncompeting interests and different immediate priorities in their respective neighborhoods; both nations will have time to adjust to each other's geopolitical needs and interests, hopefully delaying or even halting any sort of downgrade in relations.
Despite what it may seem like at times, both Iran and Pakistan are quite sensitive to each other's interests, considering they're both immediate neighbors. CPEC has also helped to bring both nations together, as Chabahar seems to be stuck in its tracks, despite India's assurances of its financial and political support. Right now, the two major issues between Pakistan and Iran seem to be border management, and Iran's conflict with KSA, which both Iran and KSA seem to be actively fighting within Pakistan, through the use of militias, politicians and sectarian extremist groups. With Iran, Pakistan needs to incentives economics, so that Iran will see more benefits from supporting Pakistan geopolitically, instead of competing against it, this may be the only way mutually beneficial way to pacify Iran.
Of course, these are simply my own views, so take them with a pinch of salt.