This is a NOTAM (Notice to Airmen) issue from FAA, advising all Commercial American Airmen (which is the one that under their jurisdiction) to avoid flying to and from Pakistan due to the MANPAD threat.
This does not just include Airline, leisure flyer, commercial (private plane) or cargo fliers was also included in this NOTAM as they are all Commercial Airmen. So for example, this Notice would be a reminder for Cargo/Freight company operator or Private/Commercial (like Lear Jet Pilot) that MANPAD threat are high in those area.
I am pretty sure DHL and Fedex operate to and from Pakistan, as well as some Private Charter Flight Company.