That was a focussed operation with narrowly defined goals and a specific target. Neither the target (OBL) nor the goals (neutralizing AQ leadership) were of importance to Pakistan's National security (considering he was not suspected to be in Pakistan).
That said, I'm not denying that the US has the military capabilities to destroy (missile, drone, bombers) Pakistan's nuclear infrastructure of it wanted to, but you're not going to see SOCOM on the ground in any such action, without Pakistan's ground forces being neutralized first.
Even US missile, drone, bomber attacks are out of the question unless a major terrorist attack on US soil is traced back to Pakistani State institutions, or the Pakistan Army collapses in its current form.
More and more it appears that the US born and bred husband in the husband-wife terrorist duo in San Bernardino, who seemingly never visited Pakistan, was radicalized and building pipe bombs with his neighbor long before meeting Tashfeen Malik.