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Real-time update on coronavirus outbreak

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Coronavirus 'spike' protein just mapped, leading way to vaccine
By Yasemin Saplakoglu - Staff Writer 9 days ago

The coronavirus uses this protein to invade human cells.
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This is the 3D atomic scale map or molecular structure of the SARS-2-CoV protein "spike" which the virus uses to invade human cells.
(Image: © Jason McLellan/Univ. of Texas at Austin)

Researchers worldwide are racing to develop potential vaccines and drugs to fight the new coronavirus, called SARS-Cov-2. Now, a group of researchers has figured out the molecular structure of a key protein that the coronavirus uses to invade human cells, potentially opening the door to the development of a vaccine, according to new findings.

Previous research revealed that coronaviruses invade cells through so-called "spike" proteins, but those proteins take on different shapes in different coronaviruses. Figuring out the shape of the spike protein in SARS-Cov-2 is the key to figuring out how to target the virus, said Jason McLellan, senior author of the study and an associate professor of molecular biosciences at the University of Texas at Austin.

Still, McLellan thinks a vaccine is likely about 18 to 24 months away. That's "still quite fast compared to normal vaccine development, which might take like 10 years," he said.

The findings were published today (Feb. 19) in the journal Science.

https://www.livescience.com/coronav...Kdu3nkJ-MSmvK6tvNqs673lbkXkHjKUaGn_046xQubpqU
 
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UPDATE
Total accumulated confirmed cases was about 80,000, and the current balance is about 30,000. By late March or early April will see most cases cleared.

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Update Global cases (Excluding China). Data updated as at 2020-03-05 22:28PM Beijing time.

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China’s SOEs develop full industrial chain to make face masks
By Zhang Hongpei Source:Global Times Published: 2020/3/5 22:03:40

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An employee of Chinese face mask maker Dasheng Health Products Manufacture Co works at the company's factory in Shanghai, East China on Friday. Photo: Yang Hui/GT

Chinese state-owned enterprises (SOEs) have played a bedrock role in the fight against the deadly coronavirus. Apart from rushing huge donations to hard-hit Hubei Province, they have also wasted no time responding to emergent market needs by exploring and developing a full industrial chain to produce key health products.

China Petroleum & Chemical Corp (Sinopec), the state-run oil giant, has established a full industrial chain including from upstream to downstream products: polypropylene, a special material to make melt-blown fabric, the melt-blown fabric itself and the ultimate product - face masks.

The company announced on February 24 that it will invest 200 million yuan ($28.8 million) to build 10 melt-blown non-woven fabric assembly lines in Beijing and East China's Jiangsu Province, with the two lines in Beijing scheduled to start partial production in March and other assembly lines to start from April, according to a statement Sinopec sent to the Global Times.

Production lines in Beijing, which could go into operation on Sunday at the earliest, are estimated to generate 4 tons of melt-blown fabric for making 1.2 million high-level N95 masks, which are needed by frontline medical workers.

China doesn't make much melt-blown fabric and the expanded production lines can hardly meet the growing speed of the downstream mask-making machines, posing a bottleneck for the whole industrial chain, a Sinopec spokesperson said.

From Tuesday, Sinopec began selling disposable masks at 50 of its gas stations in Beijing with a daily supply of 30,000 masks. Each customer is limited to buy 10 masks per week at a cost of 3.5 yuan.

And, state-run shipbuilding giant China State Shipbuilding Corp dispatched its first batch of N95 mask-making machines on Tuesday, each producing 60 masks per minute. A total of 30 such machines could roll off the line by the middle of this month, the company said.

"It is a smart move by the SOEs to leverage their material advantages and help ease market supply pressure, which is mostly out of their responsibility to stand up and help the country in time of emergency," Dong Xiucheng, professor at the University of International Business and Economics, told the Global Times on Thursday.

"It remains to be seen whether the SOEs would keep their mask assembly lines in operation after the epidemic comes to an end someday," said Dong.

The work resumption rate of centrally administered SOEs and their subsidiaries has so far surpassed 90 percent, official data showed.

The National Development and Reform Commission, China's economic planner, said on Monday that China's daily capacity and output of masks have both exceeded 100 million per day, largely easing the supply-demand gap, fivefold the production capacity one month ago.

In overseas markets, masks remain in very short supply. There were 14,942 confirmed cases of coronavirus infection outside China as of Thursday, with South Korea, Italy, Iran and Japan having seen the most infection cases.

A report from South Korea's KBS said on Thursday that the government has said each person can buy at most two masks per week. The country's confirmed cases surpassed 6,000 on Thursday.

South Korea's daily output of masks is 10 million and the government has ordered manufacturers to supply 80 percent of the output, from the previous 50 percent, to post offices, pharmacies and agricultural cooperatives. And, the government said mask exports would be banned from Friday.

In Japan, where a mask supply crunch is lingering, people also find masks out of stock in stores or subject to purchase limitations. Candy, who lives in Kyoto, told the Global Times on Thursday that "if you queue early in the morning outside the drugstores, you might have the luck to get one but maybe only one as some stores have restrictions."

https://www.globaltimes.cn/content/1181731.shtml

 
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I found this video of an Arab in Wuhan, he himself was infected with Covid-19 & recovered, he talks in detail about his symptoms.


brief translation:
1-extremely high fever, felt like my body was on fire.
2-felt extreme pressure on my body, almost as if my blood is about to burst out of my body, increased heart rate.
3-inflamed lymph nodes.
4-extreme ringing in the ear.
5-difficulty in opening the eyes.
6-extremely dry mouth.
7-"the most difficult for me was the lungs, felt like a nail is entering my chest from front to back".
8-"I was unable to sit, felt like my spine was about to jump out of my head".

difference between the influenza (common cold) & Covid-19:-
"the symptoms of influenza are totally different from that of the coronavirus, with the influenza you will have a runny nose, some coughing & bodily weakness/fatigue, but with coronavirus it's different, from one day to one month you may have no symptoms at all, but when the symptoms do appear they appear all of a sudden at full power, not gradually as some people say, all of my other friends (Pakistanis, Russians) also experienced the same exact thing, they had absolutely no symptoms & then all of a sudden the symptoms appeared & the symptoms where at their max severity right at the beginning".
 
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Global COVID-19 Update

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China Update
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the reason why I shared the previous video in the post #475 is because back on the SDF there were quite alot of idiots (mainly Xi Jinping worshippers) who kept on saying Covid-19 is just like the flu, yet here we have a patient who had personal experience with both diseases & he is telling us that Covid-19 is on a totally different level causing him unimaginable pain.
 
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World Health Organization info:-
The most common symptoms of COVID-19 are fever, tiredness, and dry cough.

Some patients may have aches and pains, nasal congestion, runny nose, sore throat or diarrhea. These symptoms are usually mild and begin gradually.

Some people become infected but don’t develop any symptoms and don't feel unwell. Most people (about 80%) recover from the disease without needing special treatment.

Around 1 out of every 6 people who gets COVID-19 becomes seriously ill and develops difficulty breathing. Older people, and those with underlying medical problems like high blood pressure, heart problems or diabetes, are more likely to develop serious illness.

People with fever, cough and difficulty breathing should seek medical attention.
 
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Tourists exhibiting symptoms and yet taking a plane to Singapore because testing and treatment was free.

Case 152 is an imported case involving a 65 year-old male Indonesian national who arrived in Singapore on 7 March. He is currently warded in an isolation room at Singapore General Hospital (SGH). He reported onset of symptoms on 28 February while he was in Indonesia, and had sought treatment at a hospital in Jakarta on 2 March. He presented at SGH on 7 March. Subsequent test results confirmed COVID-19 infection on 8 March afternoon.

Case 147 is an imported case involving a 64 year-old male Indonesian national who arrived in Singapore on 7 March. He is currently warded in an isolation room at NCID. He reported onset of symptoms on 3 March while he was in Indonesia. He had a fever when he arrived at Seletar Airport, and underwent a COVID-19 swab test at the checkpoint. He was conveyed by ambulance to NCID on 7 March night, and subsequent test results confirmed COVID-19 infection on 8 March morning.Prior to hospitalisation, he mostly stayed at his rental apartment in the Oxley Road area.

SHORT-TERM VISIT PASS HOLDERS TO PAY FOR OWN TREATMENT

MOH in the release also announced that from Mar 7, foreigners who are short-term visit pass holders who seek treatment for COVID-19 in Singapore will need to pay for their treatment.

"In view of the rising number of COVID-19 infections globally, and the expected rise in the number of confirmed cases in Singapore, we will need to prioritise the resources at our public hospitals," said the ministry.

MOH added that it will continue to waive COVID-19 testing fees for all short-term visit pass holders as part of public health measures to identify and initiate contact tracing for confirmed cases who may have been infectious while in Singapore.

The government will continue to pay for the COVID-19 testing fees and hospital bill in full for Singapore residents and long term pass holders who are admitted to public hospitals for COVID-19.

https://www.channelnewsasia.com/news/singapore/singapore-covid-19-cases-moh-mar-9-12518318
 
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More than 58,600 people have so far recovered from coronavirus in China. That’s more than 70% of cases reported in China as of today, and a lot more are still recovering. Latest case fatality count in Hubei is 1.5% and in China Outside Hubei is o.4%. So rest 98.5% to 99.6% are expected to recover!

Let’s go back to a China and a look at what happened to China during its earlier and peak days will give us a glimpse of what happens elsewhere.

On February 6 2020 - there were 3722 new cases of COVID-19 in China

That number has steadily gone down since then -
As of March 9 2020 there were 45 new cases of COVID-19 in China, although China is testing thousands times more people daily these day.

China didn’t develop any vaccine yet - they closed down Hubei province but rest of China remained open like rest of the world. They have contained the outbreak by standard public health measures.

To be able to give an accurate death rate / case fatality rate - it needs time and massive scale study. We’ll get those hopefully next year. So far studies coming out of China is saying that it hits hard early (Because it’s diagnosed in already very slick people) then tames down. One study showed that during early weeks in Hubei province - the death rate was 70% which, within one month went down to 1.5%.

More than 58,600 people have so far recovered from coronavirus in China. That’s more than 70% of cases reported in China as of today, and a lot more are still recovering. Latest case fatality count in Hubei is 1.5% and in China Outside Hubei is o.4%. So rest 98.5% to 99.6% are expected to recover!
 
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