LOL.
US could barely strangle Iran, let alone "destroy" it, with all the sanctions in the world (with even Chinese, Europeans, and Russians being on board with sanctions).
Pakistan is much more an important player, especially for China and Arab World. Stop living in fool's paradise.
And Pakistan won't ever threaten Israel with nukes unless Israel does something extremely insane---in which case, Israelis will be responded in same mannerism and not f*cks would be given to U.S or anybody else---just like no fucks were given to U.S when we followed our nuclear policy or Afghan policy for that matter.