Mammoth DNA has been implanted into functioning elephant cells

[janon]

oh, i am a lowly computing scientist myself, my ladyship... i have been designing a lowly clock-less microprocessor... i am foolish to do so since neither intel nor ibm have designed a clock-less one.

Both IBM and Intel have developed clockless chips. So has Sun microsystems.

Technology Review - It's Time for Clockless Chips

 

[Dubious]

Both IBM and Intel have developed clockless chips. So has Sun microsystems.

Technology Review - It's Time for Clockless Chips

not related...Open your own thread on your work!

 

[jamahir]

Both IBM and Intel have developed clockless chips. So has Sun microsystems.

Technology Review - It's Time for Clockless Chips

this says simply why those chips have not been released by those capitalist organizations...

"If you get three times the power going with an asynchronous design, but it takes you five times as long to get to the market—well, you lose," says Intel senior scientist Ken Stevens,

arm also had a clock-less project in collaboration ( with philips, i think )... and there is the list of projects in that article about clock-less projects... they have the cowardice typical of big capitalist computer companies... hesitation if replacing the current "market" with a new system of computing.

not related...Open your own thread on your work!

righto... @janon i have created a thread for computing... i will tag you from there.

akheilos,
goodbye, o strange one.

 

[Dubious]

righto... @janon i have created a thread for computing... i will tag you from there.

akheilos,
goodbye, o strange one.

Thank you!

 

[janon]

not related...Open your own thread on your work!

I was rebutting a factual claim on a science thread. It is important to call out factually incorrect statements, especially on a science thread. The post was as short as possible, and was more informative than your quibbles with another member. So spare me the admonitions of being off topic - you have made several unnecessary posts yourself, simply to satisfy your daily quota of bellicosity.

 

[Dubious]

I was rebutting a factual claim on a science thread.

Under the wrong topic! Or is it a habit to blindly enter / barge in the correct section but wrong thread to discuss anything you wish? Then why have threads?

It is important to call out factually incorrect statements, especially on a science thread. The post was as short as possible, and was more informative than your quibbles with another member. So spare me the admonitions of being off topic - you have made several unnecessary posts yourself, simply to satisfy your daily quota of bellicosity.

2 wrongs does not make a right...Kindly leave and delete your posts on the way...

@WebMaster @Horus @Jungibaaz @Manticore @waz @Jango @T-Faz @TaimiKhan @blain2 @Oscar @Chak Bamu May I please request a thread clean? The sole purpose of the thread was to either discuss gene technology / splicing/ DNA manipulation and its advancements (according to science)...

None of which is our neighbour here is trying to defend after talking about

 

[WAJsal]

Sounds interesting,@levina ,@SvenSvensonov ,@Pomegranate .

 

[TimeTraveller]

And so it begins.
BEC CREW
24 MAR 2015

Scientists have been discussing and debating over it for years, and now the first real step towards bringing the extinct woolly mammoth back from the dead is complete.

A renowned geneticist in the US has extracted DNA from the frozen remains of a long-dead mammoth found on Wrangel Island in the Arctic Ocean, created a synthetic replica of it, and implanted it into elephant cells that have been isolated in a petri dish, using a new technique of DNA splicing that allows for unprecedented accuracy. He reports that, so far, the altered elephant cells have been functioning perfectly.

Lead scientist George Church, a professor of genetics at Harvard University, and his team weren’t able to synthesise the entire woolly mammoth genome, but instead selected genes that encoded particularly ‘mammoth-like’ characteristics, such as cold-busting fat, ear size, and a woolly coat.

"We prioritised genes associated with cold resistance including hairiness, ear size, subcutaneous fat and, especially haemoglobin," Church told Ben Webster at The Sunday Times. Haemoglobin is what scientists think helped the mammoths survive such a frigid climate thousands of years ago. "We now have functioning elephant cells with mammoth DNA in them. We have not published it in a scientific journal because there is more work to do, but we plan to do so."

If Church’s experiments go as planned, this could be the first time we see a woolly mammoth alive in more than 3,300 years.

The technique used to join synthetic mammoth DNA fragments with the genetic code of an elephant is called CRISPR/Cas9, and while it’s been recently used to create transgenic organisms, this is the first time it’s been used on the DNA of an extinct organism.

The next step will be for the team to figure out how to replicate the process using elephant cells in situ, rather than in a petri dish. If they can do that using elephant eggs, they could theoretically produce an elephant with mammoth traits. But that’s a big “if”. And is that something we really want to do? As biologist Alex Greenwood from the Leibniz Institute for Zoo and Wildlife Research in the US told Sarah Knapton at The Telegraph:

"We face the potential extinction of African and Asian elephants. Why bring back another elephantid from extinction when we cannot even keep the ones that are not extinct around? What is the message? We can be as irresponsible with the environment as we want. Then we'll just clone things back?

Money would be better spent focusing on conserving what we do have than spending it on an animal that has been extinct for thousands of years."

Three separate teams around the world are working on resurrecting the woolly mammoth right now, so the ethical conversation might be too late, but at least we’re having it. It’s often pretty redundant to discuss how funds for one scientific experiment could be better served elsewhere because it’s a whole lot more complicated than that. But I think in this case it’s pretty valid. We’re never going to stop the mammoth revival train - unless of course we make it illegal - but anything to get endangered animals into the spotlight has to be valuable.

Sources: The Telegraph, The Sunday Times


Mammoth DNA has been implanted into functioning elephant cells - ScienceAlert


This is slightly exciting and scary...I mean the article -at least to me doesnt reveal enough to feed on. I know splicing method infact have used it (though not CRISPR/Cas9 nor at this level more at gene level than genome level) and study it in situ (again not organism level and def not animals)...

However, I agree money should be spent on conserving what we have than reviving one that is long dead!

For those who want to know more of this CRISPR/Cas 9 thing : CRISPR/Cas9 and Targeted Genome Editing:A New Era in Molecular Biology | NEB

In the acquisition phase, foreign DNA is incorporated into the bacterial genome at the CRISPR loci. CRISPR loci is then transcribed and processed into crRNA during crRNA biogenesis. During interference, Cas9 endonuclease complexed with a crRNA and separate tracrRNA cleaves foreign DNA containing a 20-nucleotide crRNA complementary sequence adjacent to the PAM sequence. (Figure not drawn to scale.)

A. Wild-type Cas9 nuclease site specifically cleaves double-stranded DNA activating double-strand break repair machinery. In the absence of a homologous repair template non-homologous end joining can result in indels disrupting the target sequence. Alternatively, precise mutations and knock-ins can be made by providing a homologous repair template and exploiting the homology directed repair pathway.
B. Mutated Cas9 makes a site specific single-strand nick. Two sgRNA can be used to introduce a staggered double-stranded break which can then undergo homology directed repair.
C. Nuclease-deficient Cas9 can be fused with various effector domains allowing specific localization. For example, transcriptional activators, repressors, and fluorescent proteins.

@Slav Defence @SvenSvensonov @Gufi @TimeTraveller @Jungibaaz @Manticore (not sure if you are interested let me know and wont mention you again) @Emmie @rockstar08 @chauvunist @syedali73 @A1Kaid

Thanks For Tagging Sir.......And Sorry for answering so late.........
......Please don't harm me...I am just a stupid little boy....