Clinical human trials begin for COVID-19 vaccine in China
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Can ancient botanical therapies help treat COVID-19?
A novel study is assessing whether medicinal mushrooms and Chinese herbs provide therapeutic benefit in treating acute COVID-19 infection. MACH-19 (Mushrooms and Chinese Herbs for COVID-19)—a multi-center study led by University of California San Diego and UCLA, in collaboration with the La...
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www.chinadaily.com.cn
China's new COVID-19 treatment approved by 15 countries
JS016, a COVID-19 treatment with China's independent intellectual property, has been approved for emergency use by 15 countries, with the combination of another neutralizing antibody, CCTV News reported on Friday morning.
www.chinadaily.com.cn
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This is for clinical treatment of COVID-19, not vaccine.
Fosun Pharma, a large Chinese pharma group has bought the rights to antiandrogen Proxalutamide for India and Africa, adding to the credibility of that spectacularly effective Covid treatment that has the potential to change the course of the pandemic.There is question of credibility because the reported clinical trial result is just too good.
Science magazine has an news article on this back in 7 Jul, 2021.
Science | AAAS
www.sciencemag.org
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China’s first COVID-19 antibody drug cuts hospitalizations, deaths 80%
By Liu Caiyu and Zhao Juecheng
Published: Dec 09, 2021 07:43 PM
China’s first home-developed anti-COVID-19 drug using “antibody cocktail therapy” has been approved for marketing, after being found to be effective in reducing the risk of hospitalization or death among high-risk COVID-19 patients by 80 percent. It also retains its neutralizing activity against the Omicron variant.
The drug shows excellent safety and protection effects in international multi-center trials, and it is the only antibody drug in the world to have evaluated the efficacy of the treatment of patients with mutant strains and obtained the best results, Zhang Linqi, the professor who leads the research and development of the drug at Tsinghua University’s School of Medicine, told the Global Times on Thursday at the university.
Studies showed that the drug could retain neutralizing activity against numerous variants including Alpha, Delta and Omicron. In the next step, Zhang’s team will investigate the preventive effect of this “antibody cocktail therapy” among high-risk and immunocompromised people, said the professor.
With one shot, the antibody cocktail can persist in the human body for about nine to 12 months. Besides the therapeutic efficacy shown in the clinical trials, it can also be used for epidemic prevention. “Antibody drugs and vaccines complement each other. If people who have underlying or immune diseases cannot take vaccines, they could choose to take this drug instead to get antibodies against COVID-19,” Zhang said.
The antibody cocktail contains two monoclonal antibodies – Brii-196 and Brii-198 – which received emergency approval from China’s top medicine regulator, the National Medical Products Administration, on Wednesday. Its approval signifies that China has the first fully domestically developed and proven anti-COVID-19 drug that has undergone strict randomized, double-blind and placebo-controlled trials.
The therapy was jointly developed by Tsinghua University, the Third People's Hospital of Shenzhen and Brii Biosciences.
The main mechanism of the drug neutralizes the novel coronavirus, preventing the virus from being absorbed to susceptible cells and thus preventing the virus or its genetic materials from entering cells to proliferate.
The study was conducted at multiple clinical trial centers around the world, including the US, Brazil, South Africa, Mexico, Argentina and the Philippines. The clinical trial results showed that the “antibody cocktail therapy” reduces the risk of hospitalization and death among high-risk COVID-19 patients by 80 percent. Nine deaths were seen in the placebo group while there were zero deaths in the treatment group.
Since June, Brii Biosciences has been working with government agencies and hospitals to donate about 3,000 doses, which helped treat about 900 COVID-19 patients across the country, including those from Guangdong, Yunnan and Inner Mongolia.
The team submitted an application for the emergency use approval to the US Food and Drug Administration in October, which means that it is likely to be the first medication to receive emergency use authorization in a developed country.
China’s first COVID-19 antibody drug cuts hospitalizations, deaths 80%
By Liu Caiyu and Zhao Juecheng
Published: Dec 09, 2021 07:43 PM
Photo: Zhao Juecheng/GT
China’s first home-developed anti-COVID-19 drug using “antibody cocktail therapy” has been approved for marketing, after being found to be effective in reducing the risk of hospitalization or death among high-risk COVID-19 patients by 80 percent. It also retains its neutralizing activity against the Omicron variant.
The drug shows excellent safety and protection effects in international multi-center trials, and it is the only antibody drug in the world to have evaluated the efficacy of the treatment of patients with mutant strains and obtained the best results, Zhang Linqi, the professor who leads the research and development of the drug at Tsinghua University’s School of Medicine, told the Global Times on Thursday at the university.
Studies showed that the drug could retain neutralizing activity against numerous variants including Alpha, Delta and Omicron. In the next step, Zhang’s team will investigate the preventive effect of this “antibody cocktail therapy” among high-risk and immunocompromised people, said the professor.
With one shot, the antibody cocktail can persist in the human body for about nine to 12 months. Besides the therapeutic efficacy shown in the clinical trials, it can also be used for epidemic prevention. “Antibody drugs and vaccines complement each other. If people who have underlying or immune diseases cannot take vaccines, they could choose to take this drug instead to get antibodies against COVID-19,” Zhang said.
The antibody cocktail contains two monoclonal antibodies – Brii-196 and Brii-198 – which received emergency approval from China’s top medicine regulator, the National Medical Products Administration, on Wednesday. Its approval signifies that China has the first fully domestically developed and proven anti-COVID-19 drug that has undergone strict randomized, double-blind and placebo-controlled trials.
The therapy was jointly developed by Tsinghua University, the Third People's Hospital of Shenzhen and Brii Biosciences.
The main mechanism of the drug neutralizes the novel coronavirus, preventing the virus from being absorbed to susceptible cells and thus preventing the virus or its genetic materials from entering cells to proliferate.
Photo: Zhao Juecheng/GT
The study was conducted at multiple clinical trial centers around the world, including the US, Brazil, South Africa, Mexico, Argentina and the Philippines. The clinical trial results showed that the “antibody cocktail therapy” reduces the risk of hospitalization and death among high-risk COVID-19 patients by 80 percent. Nine deaths were seen in the placebo group while there were zero deaths in the treatment group.
Since June, Brii Biosciences has been working with government agencies and hospitals to donate about 3,000 doses, which helped treat about 900 COVID-19 patients across the country, including those from Guangdong, Yunnan and Inner Mongolia.
The team submitted an application for the emergency use approval to the US Food and Drug Administration in October, which means that it is likely to be the first medication to receive emergency use authorization in a developed country.
JSCh
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This is for clinical treatment of COVID-19, not vaccine.
Fosun Pharma, a large Chinese pharma group has bought the rights to antiandrogen Proxalutamide for India and Africa, adding to the credibility of that spectacularly effective Covid treatment that has the potential to change the course of the pandemic.There is question of credibility because the reported clinical trial result is just too good.
Science magazine has an news article on this back in 7 Jul, 2021.
Science | AAAS
Kintor Pharma Provides Update on One of its Three Multi-Regional Phase 3 Trials of Proxalutamide for COVID-19
/PRNewswire/ -- Kintor Pharmaceutical Limited ("Kintor Pharma," HKEX: 9939), a clinical-stage biotechnology company developing innovative small molecule and...
www.prnewswire.com
China race for Covid-19 pill treatment hit by low hospital cases
Late-stage clinical trials for Kintor Pharma’s experimental drug misses statistical criteria because of ‘changing conditions’ in US.
www.scmp.com
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