Give me a break.
People are dying in US clinical trials every year.
You said: "It can be intolerable if the subject is human."
I suggest you notify the US government that you want to stop all clinical trials in the United States.
I get annoyed when forum posters show no awareness of the real world.
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Unlucky 13: Top Clinical Trial Failures of 2016 | Genetic Engineering & Biotechnology News (December 5, 2016)
"This year’s list of failed clinical candidates includes four whose trials included
patient deaths, six drugs that touched off stock-price declines of more than 60%, and six that eliminated jobs due to trial failures."